Mammary carcinoma in a male dog: clinical and immunohistochemical characterisation

Abstract

Mammary tumors in male dogs are rare, not exceeding 2% of all cases of mammary tumors in males and females. These have proved to be mostly of low-grade malignancy and positive for the presence of estradiol receptor α. In this case report, a male mammary cancer in a mixed breed dog is shown. This case report presents a case or mammary tumor which was clinically evaluated and surgically resolved, it was also under cytological, histological and immunohistochemical assessment, by studying proteins such as estradiol receptor α and β (ERα , REβ) epidermal growth factor receptor 2 (EGFR2) vascular endothelial growth factor receptor 2 (VEGFR2), cyclooxygenase-2 (COX2) and proliferating cell nuclear antigen (PCNA). Clinical examination showed that the patient had a well-defined mass, filled with liquid, adjacent to the prepuce and forming part of the right inguinal mammary gland. Cytology and histology showed neoplastic epithelial cells, consistent with a tubular carcinoma simple type, histological grade I. When performing immunedetection, high expression of REα, REβ and EGFR2 and absence of expression of COX2 and VEGFR2 were detected. These immunological results are consistent with the clinical and histological finds of the studied tumor.