Prognostic factors in subserous gallbladder cancer

Abstract

Introduction: It is important to identify the prognostic factors of the gallbladder cancer dye to be able to raise different therapies within this group tumor. 
Objective: To evaluate prognostic factors that affect the survival of patients with subserous gallbladder cancer. 
Material and methods: retrospective cohort study. We analyze the patients with histopathological diagnosis of subserous gallbladder cancer (T2) from the biopsy of the surgical specimen, operated in the Regional Hospital Valdivia (HRV) between the years 2001-2005. To characterize the population descriptive statistical analysis was carried out. Overall survival was described by Kaplan Meier curves. To measure the prognostic factors ( reoperation, adjuvant therapy (chemo), degree of differentiation and commitment linfonodal), bivariate analysis was performed using the Long rank test and multivariate analysis by means of a Cox's regression. 
Results: The cohort included 18 patients. Average age 65 (39-86) years. A predominance of females, 12 (66.66%). The preoperative diagnosis "vesicular likely cancer", was found in 5 patients (27.77%), acute cholecystitis in 8 (44.44%), symptomatic cholelithiasis in 3 (16.66%). Eleven patients (61.11%) were classified as N1 and 7 (38.88%) as N0. Five tumors (27.77%) were classified as poorly differentiated, 9 (50.00%) as moderately and 3 (16.66%) as well differentiated. Four patients surgery (22.22%). The survival at 5 years was 81.71% and 18.18% for the N0 and N1 respectively. Both the bivariate analysis (p=0.0049) as the multivariate (HR:18.34; 95% CI 1.18 -283, p=0,037) showed that the linfonodal involvement is a poor prognostic factor. 
Conclusion: The linfonodal involvement would be a prognostic factor in cancer subserous vesicular.